Intravenous sulforhodamine B reduces alveolar surface tension, improves oxygenation, and reduces ventilation injury in a respiratory distress model
نویسندگان
چکیده
منابع مشابه
Sulforhodamine B interacts with albumin to lower surface tension and protect against ventilation injury of flooded alveoli.
In the acute respiratory distress syndrome, alveolar flooding by proteinaceous edema liquid impairs gas exchange. Mechanical ventilation is used as a supportive therapy. In regions of the edematous lung, alveolar flooding is heterogeneous, and stress is concentrated in aerated alveoli. Ventilation exacerbates stress concentrations and injuriously overexpands aerated alveoli. Injury degree is pr...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2021
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00421.2020